Orit Rozenblatt–Rosen

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

95h-index56.8kcitations248works16.02yr avg
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Research Topics

Single-cell and spatial transcriptomics(120), Cancer Genomics and Diagnostics(54), Cancer Immunotherapy and Biomarkers(32), Immune Cell Function and Interaction(29), T-cell and B-cell Immunology(23)

Publications245 total

TDP-43 loss induces cryptic polyadenylation in ALS/FTD
Nature Neuroscience·2025· 10 citedOpen Access
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
Nature Cancer·2025· 2 citedOpen Access
A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity
2025Open Access
Integrating Chromatin Profiling with Gene Expression to Construct Gene Regulatory Networks in Small-Cell Lung Cancer
Journal of Thoracic Oncology·2025
Single cell profiling of human airway identifies tuft-ionocyte progenitor cells displaying cytokine-dependent differentiation bias in vitro
Nature Communications·2025· 8 citedOpen Access
Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma
Cancer Cell·2025· 3 citedOpen Access
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
Cancer Cell·2025· 1 cited
SlideCNA: spatial copy number alteration detection from Slide-seq-like spatial transcriptomics data
Genome biology·2025Open Access
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
Nature·2025· 36 citedOpen Access
Author Correction: B-cell-specific checkpoint molecules that regulate anti-tumour immunity
Nature·2025Open Access
A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients
Genome biology·2025· 6 citedOpen Access
An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets
Cell Reports·2025· 2 citedOpen Access
Author Correction: Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Nature Biotechnology·2025Open Access
282 Improving solid tumor CAR-T therapies by modulating T cell transcriptional states using combinatorial <i>in vitro</i> CRISPR screening followed by <i>in vivo</i> validation
Regular and Young Investigator Award Abstracts·2024Open Access
Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView
Nature Biotechnology·2024· 47 cited
Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
2024Open Access
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Nature Immunology·2024· 30 cited
Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity
Cell Reports Medicine·2024· 15 citedOpen Access
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Nature·2024· 3 citedOpen Access
An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission
Nature Communications·2024· 47 citedOpen Access
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Frequent Co-authors

Aviv Regev(37), Danielle Dionne(17), Itay Tirosh(14), Christopher Rodman(12), Orr Ashenberg(11), Mario L. Suvà(9), Michael S. Cuoco(9), Julia Waldman(9), Michal Slyper(8), Lan Nguyễn(8), Alex K. Shalek(7), B Bernstein(7), Monika S. Kowalczyk(7), Benjamin Izar(6), Asaf Rotem(6), David N. Louis(6), Christopher S. Smillie(6), Bruce E. Johnson(6), Matan Hofree(6), Matthew Meyerson(6)