Matan Hofree

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index13.4kcitations117works12.62yr avg
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Research Topics

Cancer Genomics and Diagnostics(31), Single-cell and spatial transcriptomics(20), Cancer Immunotherapy and Biomarkers(19), Bioinformatics and Genomic Networks(17), Prostate Cancer Treatment and Research(13)

Publications117 total

Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer
Cancer Epidemiology Biomarkers & Prevention·2025
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
eLife·2025· 1 citedOpen Access
Author response: Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
2025Open Access
Author response: Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
2025Open Access
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
2025Open Access
Germline predisposition to oncogenic alkylating damage in colorectal cancer
2025Open Access
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
eLife·2025Open Access
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
2025· 1 citedOpen Access
Author response: Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
2025Open Access
Abstract A052: <i>RNF43</i> p.G659fs mutation in MSI-high colorectal cancer leads to natural killer cell dysfunction
Cancer Immunology Research·2024
Elucidating early intestinal stem cell response to bacterial infection
2024· 2 cited
Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice
Nature Communications·2024· 57 citedOpen Access
Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness
Nucleic Acids Research·2024· 9 citedOpen Access
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
Nature Immunology·2024· 107 citedOpen Access
Telocyte networks are an essential stem cell niche component in hair follicle regeneration
2023· 3 citedOpen Access
Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response
2023· 19 citedOpen Access
Supplementary Figures and Legends from Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer
2023Open Access
Table S2: CRC risk and DNA repair genes evaluated for germline alterations from Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer
2023Open Access
Data from Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer
2023Open Access
Table S1: Somatic Mutations from Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer
2023Open Access
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Frequent Co-authors

Aviv Regev(19), Trey Ideker(16), Orit Rozenblatt–Rosen(15), Danielle Dionne(11), Lan Nguyễn(7), Orr Ashenberg(7), Hannah Carter(7), Christopher S. Smillie(6), Julia Waldman(6), Benjamin Izar(6), Jonathan Chen(6), Genevieve M. Boland(6), Nir Hacohen(6), Moshe Biton(5), Caroline Porter(5), Isaac Wakiro(5), Mei-Ju Su(5), Asaf Rotem(5), Karin Pelka(5), Siranush Sarkizova(5)