Claus V. Hallwirth

University of Sydney — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index613citations24works0.02yr avg
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Research Topics

Virus-based gene therapy research(16), CRISPR and Genetic Engineering(11), Infectious Diseases and Mycology(4), RNA Interference and Gene Delivery(3), Plant Virus Research Studies(2)

Publications24 total

A bioinformatic pipeline for simulating viral integration data
Data in Brief·2022· 1 citedOpen Access
Isling: A Tool for Detecting Integration of Wild-Type Viruses and Clinical Vectors
Journal of Molecular Biology·2021· 5 citedOpen Access
Restoring the natural tropism of AAV2 vectors for human liver
Science Translational Medicine·2020· 56 cited
Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2
Molecular Therapy — Methods & Clinical Development·2020· 44 citedOpen Access
Efficient in vivo editing of OTC-deficient patient-derived primary human hepatocytes
JHEP Reports·2019· 31 citedOpen Access
Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality
Molecular Therapy — Methods & Clinical Development·2018· 35 citedOpen Access
NOVEL CAPSID SEQUENCES FROM ANCIENT AND CONTEMPORARY ADENO-ASSOCIATED VIRUSES IN AUSTRALIAN MARSUPIALS
The Journal of Gene Medicine·2018
Identification of liver-specific enhancer–promoter activity in the 3′ untranslated region of the wild-type AAV2 genome
Nature Genetics·2017· 95 cited
Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data
BMC Bioinformatics·2017· 6 citedOpen Access
Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency
Molecular Therapy — Nucleic Acids·2016· 24 citedOpen Access
Germline viral “fossils” guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus
Scientific Reports·2016· 38 citedOpen Access
541. Use of Endogenous Viral Elements to Deduce the Sequence of an Ancient Adeno-Associated Virus That Circulated Amongst Australian Marsupials ~30 Million Years Ago
Molecular Therapy·2016Open Access
298. Characterization of a Novel Anti-Sense Promoter Element in Adeno-Associated Virus: Implications for Hepatocellular Carcinoma
Molecular Therapy·2016Open Access
700. Stable Correction of Severe Metabolic Liver Disease Phenotypes in the Growing Murine Liver Using a Hybrid rAAV/piggyBac Transposon Gene Delivery System
Molecular Therapy·2015Open Access
Probing the closed-loop model of mRNA translation in living cells
Figshare·2015Open Access
Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno‐associated virus/piggyBac transposase gene delivery system
Hepatology·2015· 47 cited
Probing the closed-loop model of mRNA translation in living cells
RNA Biology·2015· 61 citedOpen Access
Coherence analysis discriminates between retroviral integration patterns in CD34+ cells transduced under differing clinical trial conditions
Molecular Therapy — Methods & Clinical Development·2015· 1 citedOpen Access
Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence
Nucleic Acids Research·2014· 34 citedOpen Access
Analysis and comparison of γ-retroviral vector integration behaviour in human CD34+cells transduced under conditions employed in the French and English SCID-X1 clinical trials
2013
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Frequent Co-authors

Ian E. Alexander(18), Samantha L. Ginn(9), Nicola Hetherington(7), Sophia H.Y. Liao(6), Leszek Lisowski(6), Adrian J. Thrasher(5), Grant J. Logan(4), Anais K. Amaya(4), Erhua Zhu(4), Sharon C. Cunningham(4), Marti Cabanes‐Creus(4), Suzanne Scott(4), Mavis Agbandje‐McKenna(4), Gagan Garg(4), Hung Fan(3), Natsuki Sasaki(3), Adrian Westhaus(3), Giorgia Santilli(3), Kimberley L. Dilworth(3), Robert M. Kotin(3)