John H. Bushweller

Medicine · Health Sciences

50h-index9.0kcitations189works1.72yr avg
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Research Topics

Acute Myeloid Leukemia Research(54), Protein Degradation and Inhibitors(36), Genomics and Chromatin Dynamics(19), Ubiquitin and proteasome pathways(18), Enzyme Structure and Function(16)

Publications189 total

Backbone 1H, 15N Chemical Shift Assignments of Human MLLT3 YEATS domain in presence of SL4 of 7SK ncRNA
Biological Magnetic Resonance Bank·2026Open Access
Chemical Shift assignments of Human MLLT3 YEATS domain
Biological Magnetic Resonance Bank·2026Open Access
Backbone 1H, 15N Chemical Shift Assignments of Human MLLT3 YEATS domain (K63EK67E double mutant)
Biological Magnetic Resonance Bank·2026Open Access
Backbone 1H, 15N Chemical Shift Assignments of Human MLLT3 YEATS domain (K63EK67E double mutant) in presence of SL4 of 7SK ncRNA
Biological Magnetic Resonance Bank·2026Open Access
The MLLT3 YEATS domain is a dual reader of histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking epigenetic and RNA signaling to regulate hematopoiesis
2025Open Access
Abstract 5739: Small molecule modulation of autoinhibition to inhibit DNA binding of ERG and FLI1 - therapeutic for Ewing sarcoma, prostate cancer, and ALL
Cancer Research·2025
<scp>FGFR2</scp>‐<scp>RUNX2</scp> activation: An unexplored therapeutic pathway in luminal breast cancer related to tumor progression
International Journal of Cancer·2024· 2 cited
The co-receptor Neuropilin-1 enhances proliferation in inv(16) acute myeloid leukemia via VEGF signaling
Leukemia·2024· 6 citedOpen Access
Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
iScience·2024· 9 citedOpen Access
Abstract 1092: RUNX2 inhibition alters PAX3::FOXO1 driven fusion-positive rhabdomyosarcoma cell state and growth
Cancer Research·2024Open Access
N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia
Science Advances·2024· 3 citedOpen Access
Recombinant expression and purification of human EP300-KIX87 domain from&amp;#160;Escherichia coli
BIO-PROTOCOL·2024Open Access
Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth
Cell Reports·2023· 12 citedOpen Access
P444: SINGLE CELL RNASEQ UNCOVERING THE ROLE OF A LEUKEMIC DRIVER GENE FUSION CBFΒ::MYH11 IN THE LEUKEMIC–NICHE SIGNALING
HemaSphere·2023Open Access
Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth
2023· 4 citedOpen Access
Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability
Nature Communications·2022· 22 citedOpen Access
Small-Molecule Inhibitors of the MLL1 CXXC Domain, an Epigenetic Reader of DNA Methylation
ACS Medicinal Chemistry Letters·2022· 9 citedOpen Access
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer
Science Advances·2022· 33 citedOpen Access
3053 – DEFINING THE GENE REGULATORY NETWORKS TARGETED BY RUNX1 AND FLT3 INHIBITORS
Experimental Hematology·2022
The CBFβ-SMMHC/NRP1 Axis Regulates FLT3 and TGF-Beta Pathways in Inv(16) Acute Myeloid Leukemia
Blood·2021
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Frequent Co-authors

Nancy A. Speck(13), Tomasz Cierpicki(10), Jolanta Grembecka(7), Lukas K. Tamm(6), Yunpeng Zhou(6), Stephen M. Lukasik(6), Anuradha Illendula(6), David S. Cafiso(4), Aravinda Kuntimaddi(4), Liya Roudaia(4), John Anto Pulikkan(4), Lucio H. Castilla(4), Marcelo J. Berardi(4), Frits Abildgaard(3), Nancy J. Zeleznik‐Le(3), Arne Holmgren(3), Kurt Wüthrich(3), Matthew D. Cheney(3), Takeshi Corpora(3), Amy F. Lewis(2)