Zhefu Que

Purdue University West Lafayette — United States

Neuroscience · Life Sciences

8h-index337citations16works10.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(7), Neuroinflammation and Neurodegeneration Mechanisms(6), Ion channel regulation and function(5), Autism Spectrum Disorder Research(4), Neurogenesis and neuroplasticity mechanisms(4)

Publications16 total

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation
Science Advances·2026Open Access
Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids
2025Open Access
Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation: Microglial diversity and response in assembloids
2025· 3 citedOpen Access
Autism-associated <i>SCN2A</i> deficiency disrupts cortico-striatal circuitry in human brain assembloids
2025· 2 citedOpen Access
Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated <i>Scn2a</i> -deficiency
2025· 8 cited
Human IPSC-Derived Microglia Sense and Dampen Hyperexcitability of Cortical Neurons Carrying the Epilepsy-Associated<i>SCN2A</i>-L1342P Mutation
Journal of Neuroscience·2024· 9 citedOpen Access
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
Molecular Psychiatry·2024· 48 cited
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation
2023· 4 citedOpen Access
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
2023· 13 citedOpen Access
Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms
Neurobiology of Disease·2022· 32 citedOpen Access
Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant
Journal of Neuroscience·2021· 47 citedOpen Access
Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
Cell Reports·2021· 117 citedOpen Access
Multi-Electrode Array of Sensory Neurons as an In Vitro Platform to Identify the Nociceptive Response to Pharmaceutical Buffer Systems of Injectable Biologics
Pharmaceutical Research·2021· 10 cited
Severe deficiency of voltage-gated sodium channel Na <sub>V</sub> 1.2 elevates neuronal excitability in adult mice
2021· 2 citedOpen Access
Sodium channel Nav1.2-L1342P variant displaying complex biophysical properties renders hyperexcitability of cortical neurons derived from human iPSCs
2021· 3 citedOpen Access
Generation and basic characterization of a gene‐trap knockout mouse model of <i>Scn2a</i> with a substantial reduction of voltage‐gated sodium channel Na<sub>v</sub>1.2 expression
Genes Brain & Behavior·2020· 39 citedOpen Access

Frequent Co-authors

Jingliang Zhang(15), Yang Yang(14), Xiaoling Chen(13), Jiaxiang Wu(12), William C. Skarnes(11), Kyle Wettschurack(11), Muriel Eaton(10), Maria I. Olivero-Acosta(10), Chris Yuan(10), Tiange Xiao(9), Yuanrui Zhao(8), Manasi Halurkar(7), Nadia A. Lanman(6), Zhuo Huang(5), Ningren Cui(5), Long‐Jun Wu(5), Jean‐Christophe Rochet(5), Morgan Robinson(5), Zhixiong Ma(4), Ian Chen(4)