Maria I. Olivero-Acosta

Purdue University West Lafayette — United States

Neuroscience · Life Sciences

5h-index240citations10works13.42yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(5), Ion channel regulation and function(4), Neuroinflammation and Neurodegeneration Mechanisms(3), Autism Spectrum Disorder Research(2), Adenosine and Purinergic Signaling(2)

Publications10 total

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids
2025Open Access
Autism-associated <i>SCN2A</i> deficiency disrupts cortico-striatal circuitry in human brain assembloids
2025· 2 citedOpen Access
Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated <i>Scn2a</i> -deficiency
2025· 8 cited
Human IPSC-Derived Microglia Sense and Dampen Hyperexcitability of Cortical Neurons Carrying the Epilepsy-Associated<i>SCN2A</i>-L1342P Mutation
Journal of Neuroscience·2024· 9 citedOpen Access
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
Molecular Psychiatry·2024· 48 cited
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation
2023· 4 citedOpen Access
Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant
Journal of Neuroscience·2021· 47 citedOpen Access
Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice
Cell Reports·2021· 117 citedOpen Access
Severe deficiency of voltage-gated sodium channel Na <sub>V</sub> 1.2 elevates neuronal excitability in adult mice
2021· 2 citedOpen Access
Sodium channel Nav1.2-L1342P variant displaying complex biophysical properties renders hyperexcitability of cortical neurons derived from human iPSCs
2021· 3 citedOpen Access

Frequent Co-authors

Jingliang Zhang(10), Zhefu Que(10), Xiaoling Chen(9), Jiaxiang Wu(9), William C. Skarnes(9), Yang Yang(9), Tiange Xiao(7), Chris Yuan(7), Kyle Wettschurack(7), Muriel Eaton(6), Manasi Halurkar(6), Nadia A. Lanman(5), Yuanrui Zhao(5), Ningren Cui(4), Jean‐Christophe Rochet(4), Muhan Wang(4), James A. Schaber(3), Zhuo Huang(3), Ian Chen(3), Ranjie Xu(3)