Yuanrui Zhao

Purdue University West Lafayette — United States

Neuroscience · Life Sciences

4h-index91citations11works8.22yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(6), Neuroscience and Neuropharmacology Research(4), Neurogenesis and neuroplasticity mechanisms(4), Genetics and Neurodevelopmental Disorders(3), Autism Spectrum Disorder Research(2)

Publications11 total

Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation
Science Advances·2026Open Access
Gene therapies alleviate absence epilepsy associated with <i>Scn2a</i> deficiency in DBA/2J mice
2025Open Access
Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation: Microglial diversity and response in assembloids
2025· 3 citedOpen Access
Autism-associated <i>SCN2A</i> deficiency disrupts cortico-striatal circuitry in human brain assembloids
2025· 2 citedOpen Access
Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated <i>Scn2a</i> -deficiency
2025· 8 cited
Human IPSC-Derived Microglia Sense and Dampen Hyperexcitability of Cortical Neurons Carrying the Epilepsy-Associated<i>SCN2A</i>-L1342P Mutation
Journal of Neuroscience·2024· 9 citedOpen Access
Extracerebral multiple organ dysfunction and interactions with brain injury after cardiac arrest
Resuscitation Plus·2024· 4 citedOpen Access
Improvement in Outcomes and Prevention of Multiple Organ Dysfunction Syndrome After Cardiac Arrest and Successful Cardiopulmonary Resuscitation by Systemic Administration of Bumetanide in Male Mice
2024Open Access
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
Molecular Psychiatry·2024· 48 cited
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation
2023· 4 citedOpen Access
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
2023· 13 citedOpen Access

Frequent Co-authors

Jingliang Zhang(8), Xiaoling Chen(8), Kyle Wettschurack(8), Zhefu Que(8), Chris Yuan(8), Yang Yang(8), Jiaxiang Wu(7), Manasi Halurkar(7), Maria I. Olivero-Acosta(5), Tiange Xiao(5), Long‐Jun Wu(5), Morgan Robinson(5), William C. Skarnes(5), Brody A. Deming(4), Ningren Cui(4), Ian Chen(4), Ranjie Xu(4), Jean‐Christophe Rochet(4), Ye-Eun Yoo(4), Muriel Eaton(3)