Sarah E. Conduit

Cancer Research UK — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index841citations18works5.32yr avg
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Research Topics

Genetic and Kidney Cyst Diseases(12), Hedgehog Signaling Pathway Studies(8), Renal and related cancers(7), PI3K/AKT/mTOR signaling in cancer(3), Genetic Syndromes and Imprinting(3)

Publications18 total

Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality
Cellular and Molecular Life Sciences·2025Open Access
Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome
Disease Models & Mechanisms·2025· 1 citedOpen Access
Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer
2025Open Access
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease
Nature Communications·2024· 11 citedOpen Access
Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice
Nature Communications·2024· 19 citedOpen Access
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Nature·2023· 138 citedOpen Access
Superresolution Microscopy Reveals Distinct Phosphoinositide Subdomains Within the Cilia Transition Zone
Frontiers in Cell and Developmental Biology·2021· 30 citedOpen Access
Phosphoinositide lipids in primary cilia biology
UCL Discovery (University College London)·2020· 36 cited
AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease
Human Molecular Genetics·2019· 25 citedOpen Access
β-catenin ablation exacerbates polycystic kidney disease progression
Human Molecular Genetics·2018· 12 citedOpen Access
A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma
Oncogene·2017· 56 citedOpen Access
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing
The Journal of Cell Biology·2017· 169 citedOpen Access
The inositol polyphosphate 5-phosphatase INPP5E regulates Sonic Hedgehog-dependent development and medulloblastoma
Figshare·2017Open Access
INPP5E regulates phosphoinositide-dependent cilia transition zone function
The Journal of Cell Biology·2016· 119 citedOpen Access
INPP5E interacts with AURKA, linking phosphoinositide signalling to primary cilium stability
Journal of Cell Science·2014· 75 citedOpen Access
Inositol polyphosphate 5‐phosphatases; new players in the regulation of cilia and ciliopathies
FEBS Letters·2012· 68 citedOpen Access
Inositol Polyphosphate Phosphatases in Human Disease
Current topics in microbiology and immunology·2012· 81 citedOpen Access

Frequent Co-authors

Christina A. Mitchell(10), Bart Vanhaesebroeck(7), Jennifer M. Dyson(7), Sandra Hakim(5), Wayne Pearce(5), Ian Smyth(4), Glenn R. Masson(3), Roger Williams(3), Denny L. Cottle(3), Mohammad Amin Danesh(3), Mahreen Adil(3), Georgia Constantinou(3), Benoît Bilanges(2), Amandeep Bhamra(2), Silvia Šurinová(2), Maria A. Whitehead(2), Sandra J. Feeney(2), Alex J. Fulcher(2), Rajendra Gurung(2), Elizabeth M. Davies(2)