Ed S. Lein

Allen Institute for Brain Science — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

78h-index49.8kcitations284works13.72yr avg
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Research Topics

Single-cell and spatial transcriptomics(154), Neuroinflammation and Neurodegeneration Mechanisms(82), Cell Image Analysis Techniques(64), Neural dynamics and brain function(43), Neuroscience and Neuropharmacology Research(37)

Publications274 total

Cross-species consensus atlas of the primate basal ganglia
2025· 5 citedOpen Access
Spatial patterning of transcriptional and regulatory programs in the primate subcortex
2025Open Access
A cross-species spatial transcriptomic atlas of the human and non-human primate basal ganglia
2025· 7 citedOpen Access
AAV-PHP.eB achieves superior neuronal transduction over AAV9 in pigtail macaques following intracerebroventricular administration
Molecular Therapy — Methods & Clinical Development·2025Open Access
A spatially-resolved human brain proteome atlas for understanding function and disease
2025Open Access
MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics
2025Open Access
Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species
2025· 1 citedOpen Access
Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species
2025Open Access
AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders
Molecular Therapy·2025· 5 citedOpen Access
HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species
2025· 1 citedOpen Access
Single-cell multiomic human brain atlas reveals regulatory drivers of cortical regionality
2025· 1 citedOpen Access
An integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease
Alzheimer s & Dementia·2025· 13 citedOpen Access
Mouse lemur cell atlas informs primate genes, physiology and disease
Nature·2025· 4 citedOpen Access
A molecular cell atlas of mouse lemur, an emerging model primate
Nature·2025· 7 citedOpen Access
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Neuron·2025· 4 citedOpen Access
Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex
Cell Genomics·2025· 12 citedOpen Access
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Cell Reports·2025· 16 citedOpen Access
Cytosplore EvoViewer: Visual Analytics of Conserved Evolutionary Patterns in multi-species single-cell sequencing data
2025
Integrating multimodal data to understand cortical circuit architecture and function
Nature Neuroscience·2025· 11 cited
MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics
2025· 1 citedOpen Access
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Frequent Co-authors

Susan M. Sunkin(21), Michael Hawrylycz(21), Amy Bernard(19), Kimberly A. Smith(19), Nick Dee(18), Trygve E. Bakken(18), Hongkui Zeng(17), Jeremy A. Miller(17), Allan R. Jones(15), Jeff Goldy(15), Lydia Ng(14), Darren Bertagnolli(14), Christof Koch(12), Aaron Szafer(12), John W. Phillips(12), Rebecca D. Hodge(12), Bosiljka Tasic(11), Tamara Casper(11), Nadiya V. Shapovalova(10), Song‐Lin Ding(10)