Nils Pfaff

Bayer (Germany) — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index547citations16works1.02yr avg
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Research Topics

Pluripotent Stem Cells Research(8), CRISPR and Genetic Engineering(8), Virus-based gene therapy research(3), Blood Coagulation and Thrombosis Mechanisms(3), Sepsis Diagnosis and Treatment(2)

Publications16 total

Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy
Journal of Medicinal Chemistry·2025Open Access
Treatment with a Novel Small Molecule Dual Factor IIa/Xa Inhibitor Protects Against Coagulopathy and Organ Dysfunction in a Baboon Model of <i>Staphylococcus Aureus</i> Sepsis
Blood·2024· 2 citedOpen Access
An <i>in vitro</i> pharmacodynamic spiking study of befovacimab, a tissue factor pathway inhibitor monoclonal antibody, in blood samples from patients with severe FVIII deficiency
Haemophilia·2021· 4 cited
Inhibition of miRNA-212/132 improves the reprogramming of fibroblasts into induced pluripotent stem cells by de-repressing important epigenetic remodelling factors
Stem Cell Research·2017· 22 citedOpen Access
miRNA CG212/132の阻害は重要な後成的リモデリング因子をde抑制による誘導多能性幹細胞への線維芽細胞のリプログラミングを改善する【Powered by NICT】
Stem Cell Research (Web)·2017
Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy
Biomaterials·2013· 64 cited
Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis
American Journal of Respiratory and Critical Care Medicine·2013· 100 cited
MicroRNA-Mediated Epigenetic Silencing of Sirtuin1 Contributes to Impaired Angiogenic Responses
Circulation Research·2013· 60 citedOpen Access
From Skin to Blood: A New Member Joins the iClub
Cell stem cell·2013· 4 citedOpen Access
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
Stem Cells·2013· 82 citedOpen Access
miRNAs involved in the generation, maintenance, and differentiation of pluripotent cells
Journal of Molecular Medicine·2012· 24 cited
The Ubiquitous Chromatin Opening Element (UCOE) Enhances Lentiviral Cytidine Deaminase (CDD) Expression and Drug Resistance During Hematopoietic Differentiation of Murine Induced Pluripotent Stem Cells (iPSCs),
Blood·2011
Doxycycline Regulatable Expression of Cytidine Deaminase Mediates Myeloprotection and Avoids Lymphotoxicity in a Murine Transplant Model
Blood·2011
miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2
EMBO Reports·2011· 96 citedOpen Access
Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells
Stem Cells and Development·2011· 30 cited
Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii
International Journal for Parasitology·2008· 59 citedOpen Access

Frequent Co-authors

Axel Schambach(9), Tobias Cantz(8), Thomas Moritz(8), Nico Lachmann(6), Mania Ackermann(4), Thomas Thum(4), Jan Fiedler(3), Saskia Kohlscheen(3), Heiner Niemann(3), Christine Happle(2), Adele Mucci(2), Sebastian Brennig(2), Gudrun Göhring(2), Gesine Hansen(2), Angelika Holzmann(2), Christian Brendel(2), Christopher Baum(2), Selina Möbus(2), Abbas Beh-Pajooh(2), Angelika Pfanne(2)