Leroy N. Hwang

National Institutes of Health — United States

Immunology and Microbiology · Life Sciences

14h-index3.0kcitations17works0.02yr avg
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Research Topics

Immunotherapy and Immune Responses(11), CAR-T cell therapy research(7), Plant Virus Research Studies(5), Virus-based gene therapy research(5), Virology and Viral Diseases(5)

Publications17 total

Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination
Blood·2009· 30 citedOpen Access
Type I Interferons are essential for the efficacy of replicase-based DNA vaccines
Vaccine·2006· 56 citedOpen Access
The<i>In vivo</i>Expansion Rate of Properly Stimulated Transferred CD8+ T Cells Exceeds That of an Aggressively Growing Mouse Tumor
Cancer Research·2006· 53 citedOpen Access
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8 <b>+</b> T cells
The Journal of Experimental Medicine·2005· 1.0k citedOpen Access
Vaccine-Stimulated, Adoptively Transferred CD8+ T Cells Traffic Indiscriminately and Ubiquitously while Mediating Specific Tumor Destruction
The Journal of Immunology·2004· 112 citedOpen Access
IFN-gamma production by adoptively transferred CD8+ T lymphocytes and host cells contributes to successful tumor immunotherapy
Journal of the American College of Surgeons·2004
Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer
Journal of Leukocyte Biology·2004· 46 citedOpen Access
IL-7 and IL-15 can trigger cancer regression after adoptive transfer of CD8+T lymphocytes
Annals of Surgical Oncology·2004
Apoptosis is essential for the increased efficacy of alphaviral replicase-based DNA vaccines
Vaccine·2003· 78 citedOpen Access
Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells
The Journal of Experimental Medicine·2003· 916 citedOpen Access
Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways
Nature Medicine·2002· 269 cited
The promise of nucleic acid vaccines
Gene Therapy·2000· 136 citedOpen Access
Optimal Replication Activity of Vesicular Stomatitis Virus RNA Polymerase Requires Phosphorylation of a Residue(s) at Carboxy-Terminal Domain II of Its Accessory Subunit, Phosphoprotein P
Journal of Virology·1999· 48 citedOpen Access
Identification and characterization of cis-acting signals in the genome of vesicular stomatitis virus that control polyadenylation, transcription termination, and transcription reinitiation
1999
Polyadenylation of Vesicular Stomatitis Virus mRNA Dictates Efficient Transcription Termination at the Intercistronic Gene Junctions
Journal of Virology·1998· 64 citedOpen Access
Phosphorylation within the amino-terminal acidic domain I of the phosphoprotein of vesicular stomatitis virus is required for transcription but not for replication
Journal of Virology·1997· 97 citedOpen Access
Basic Amino Acid Residues at the Carboxy-Terminal Eleven Amino Acid Region of the Phosphoprotein (P) Are Required for Transcription but Not for Replication of Vesicular Stomatitis Virus Genome RNA
Virology·1997· 44 citedOpen Access

Frequent Co-authors

Nicholas P. Restifo(12), Douglas C. Palmer(8), Christopher A. Klebanoff(7), Zhiya Yu(6), Luca Gattinoni(5), Steven E. Finkelstein(5), Paul A. Antony(5), Paul J. Spiess(5), David M. Heimann(5), Steven A. Rosenberg(5), Wolfgang W. Leitner(4), Asit K. Pattnaik(4), Deborah R. Surman(3), Nathan Englund(3), Claudia Wrzesinski(2), Marc R. Theoret(2), Elke S. Bergmann‐Leitner(2), Tapas Das(2), Amiya K. Banerjee(2), Christian S. Hinrichs(2)