C. Dirk Keene

Seattle Pacific University — United States

Medicine · Health Sciences

84h-index39.7kcitations540works6.82yr avg
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Research Topics

Alzheimer's disease research and treatments(151), Neuroinflammation and Neurodegeneration Mechanisms(79), Dementia and Cognitive Impairment Research(76), Traumatic Brain Injury Research(58), Traumatic Brain Injury and Neurovascular Disturbances(53)

Publications523 total

Cross-species consensus atlas of the primate basal ganglia
2025· 5 citedOpen Access
Transport of CCL2 across an induced pluripotent stem cell-derived in vitro model of the human blood-brain barrier is heparan sulfate-dependent
PLoS ONE·2025Open Access
APOE isoform‐associated tau oligomer polymorphs differ in synaptotoxicity and seeding activity
Alzheimer s & Dementia·2025Open Access
A cross-species spatial transcriptomic atlas of the human and non-human primate basal ganglia
2025· 7 citedOpen Access
Spatial Multi-Omics Workflow and Analytical Guidelines for Alzheimer’s Neuropathology
2025
Genome‐wide association studies of TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B
Alzheimer s & Dementia·2025· 1 citedOpen Access
Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions
Alzheimer s & Dementia·2025Open Access
Beyond mild, moderate, and severe traumatic brain injury: modelling severity from clinical, neuroimaging, and blood-based indicators
EBioMedicine·2025· 2 citedOpen Access
One-Year Outcomes After Traumatic Brain Injury and Early Extracranial Surgery in the TRACK-TBI Study
JAMA Network Open·2025Open Access
Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
Alzheimer s & Dementia·2025· 3 citedOpen Access
Epigenomic profile of GBA1 in Parkinson's disease
Parkinsonism & Related Disorders·2025Open Access
Chronic traumatic encephalopathy neuropathologic change in the Late Effects of Traumatic Brain Injury project: Findings in a community autopsy cohort
Journal of Neuropathology & Experimental Neurology·2025· 1 citedOpen Access
Evidence for axonal beading and loss in traumatic brain injury using ultra-high gradient ex vivo diffusion MRI
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2025
MicroRNA cargo in neuron‐derived vesicles as peripheral biomarkers of brain insulin dysregulation
Alzheimer s & Dementia·2025Open Access
The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and <i>post mortem</i> protocols
Alzheimer s & Dementia·2025Open Access
Vascular Risk Factors and 1-Year Cognitive Change Among Individuals With Traumatic Brain Injury
JAMA Network Open·2025· 2 citedOpen Access
Single-cell multiomic human brain atlas reveals regulatory drivers of cortical regionality
2025· 1 citedOpen Access
Deep learning-based cell type profiles reveal signatures of Alzheimer’s disease resilience and resistance
Brain·2025· 2 citedOpen Access
Huntingtin preserves mitochondrial genome integrity in neurons, which is impaired in Huntington’s disease
2025Open Access
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Neuron·2025· 4 citedOpen Access
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Frequent Co-authors

Ed S. Lein(13), Nick Dee(11), Rebecca D. Hodge(9), Kimberly A. Smith(9), Tamara Casper(9), Jeff Goldy(9), Trygve E. Bakken(8), Darren Bertagnolli(8), Paul K. Crane(8), Song‐Lin Ding(7), Nadiya V. Shapovalova(7), Michael Tieu(7), Julie A. Schneider(7), Kimberly Siletti(7), Anna Marie Yanny(7), Jeremy A. Miller(6), Andrew L. Ko(6), Dennis W. Dickson(6), Thomas J. Montine(6), Nikolas L. Jorstad(6)